Skin Disorders
Bookmark and Share
   Acquired Melanocytic Nevocellular Nevi
   Acral Lentiginous Melanoma
   Acute HIV Syndrome
   Acute Lymphangitis
   Acute Sun Damage
   Adult T Cell Leukemia
   Adverse Cutaneous Drug Reactions
   Alopecia Areata
   Androgenetic Alopecia
   Aphthous Ulcer
   Bacillary Angiomatosis
   Bacterial Infections
   Basal Cell Carcinoma
   Basal Cell Nevus Syndrome
   Behcet's Syndrome
   Benign Cutaneous Neoplasms
   Capillary Hemangioma of Infancy
   Cat-Scratch Disease
   Chronic Lupus Panniculitis
   Chronic Venous Insufficiency
   Clark Melanocytic Nevus
   Congenital Nevomelanocytic Nevus
   Crest Syndrome
   Cutaneous Candidiasis
   Cutaneous Larva Migrans
   Cutaneous Lupus Erythematosus
   Cutaneous and Mucocutaneous Leishmaniasis
   Cutaneous Pseudomonas Aeruginosa Infections
   Cutaneous Reactions to Arthropod Bites
   Cutaneous T Cell Lymphoma
   Desmoplastic Melanoma
   Disseminated Coccidioidomycosis
   Disseminated Cryptococcosis
   Disseminated Gonococcal Infection
   Disseminated Intravascular Coagulation
   Drug Hypersensitivity Syndrome
   Drug-Induced Acute Urticaria
   Drug-Induced Pigmentation
   Eosinophilic Folliculitis
   Erysipelas and Cellulitis
   Erythema Infectiosum
   Erythropoietic Protoporphyria
   Exanthematous Drug Reactions
   Exfoliative Erythroderma Syndrome
   Extramammary Paget's Disease
   Eye Stye
   Fixed Drug Eruption
   Gangrenous Cellulitis
   Genital Candidiasis
   Giant Cell Arteritis
   Glucagonoma Syndrome
   Graft Versus Host Disease
   Hand-Foot-and-Mouth Disease
   Herpes Gestationis
   Herpes Simplex Virus: Genital Infections
   Herpes Simplex Virus Infection
   Herpes Simplex Virus: Infections Associated Systemic Immunocompromise
   Herpes Simplex Virus
   Herpes Zoster
   HIV Associated Lipodystrophy Syndrome
   Human Papillomavirus: Mucosal Infections
   Human Papillomavirus: Squamous Cell Carcinoma In Situ
   Human Papillomavirus
   Hypersensitivity Vasculitis
   Hypertrophic Scars and Keloid
   Impetigo and Ecthyma
   Infectious Exanthems
   Infectious Folliculitis
   Infective Endocarditis
   Infestations of the Skin
   Kaposi's Sarcoma
   Kawasaki's Disease

Home :: Eosinophilic Folliculitis

Eosinophilic Folliculitis

There are several variants of eosinophilic folliculitis, which is also known as ‘eosinophilic pustular folliculitis’ or ‘Ofuji disease’. The name is due to skin biopsy finding of eosinophils (a type of immune cell) around hair follicles.

Eosinophilic folliculitis (EF) is an idiopathic, extremely pruritic, papular follicular eruption of the upper trunk, face, neck, and proximal extremities occurring in advanced HIV disease and/or after initiation of highly active antiretroviral therapy, often associated with peripheral eosinophilia. EF occurring in HIV disease is different from that of Ofuji's disease.

Causes of Eosinophilic Folliculitis


Symptoms of Eosinophilic Folliculitis

The signs and symptoms of folliculitis vary, depending on the type of infection. In superficial forms of the disorder, small pimples develop around one or more hair follicles


Clinical diagnosis confirmed by skin biopsy, with cultures ruling out infectious causes. A new primary lesion (follicular papule) should be marked with a pen and biopsied with a 2-mm punch.


Pruritus is moderate to severe, significantly affecting quality of life. Changes secondary to chronic scratching such as secondary infections and lichen simplex chronicus also should be identified and treated. The most predictably effective therapy is a short tapered course of oral glucocorticoid such as prednisone.

Antihistamines Those causing sedation are more effective for symptomatic relief of pruritus. Doxepin, 10-100 mg, is especially effective at bedtime.

Topical Agents

  • Glucocorticoids Class I (superpotent) glucocorticoids applied to affected areas produce fair to moderate improvement in pruritus and lesions. Patients using these agents on the face should be closely monitored for atrophic changes.

Systemic Agents

  • Prednisone Initial dose of 70 mg, followed by a taper of 5-10 mg/d (14 - 7 days) provides rapid symptomatic improvement as well as resolution of EF. EF gradually recurs after completion of course.
  • Isotretinoin (Accutane) 1-2 mg/kg/d (about 80 mg) very effective in causing resolution of EF. Once symptoms and skin findings have resolved, dose is reduced to 40 mg/d for 2-4 weeks and then tapered to 40 mg qod. Dosing may be discontinued in 1-2 months if symptoms do not recur. Many HIV-infected individuals treated with HAART have elevated triglyceride levels; isotretinoin can further increase triglyceride levels.
  • Itraconazole 400 mg/d for 4 weeks reported to be effective.


  • UVB Treatments are usually given three times a week, tapering as   symptoms of EF resolve. Moderately effective.
  • Natural sunlight Many individuals cannot tolerate natural sunlight because of treatment with photosensitizing drugs such as trimethoprim­sulfamethoxazole (Bactrim), which are photosensitizing in the UVA spectrum.
More Skin Disorders
   Langerhans Cell Histiocytosis
   Leg Ulcers
   Lentigo Maligna
   Leukemia Cutis
   Livedo Reticularis
   Localized Infection
   Lupus Erythematosus
   Lyme Borreliosis
   Lymphogranuloma Venereum
   Lymphomatoid Papulosis
   Malignant Melanoma of the Mucosa
   Mammary Paget's Disease
   Mastocytosis Syndromes
   Merkel Cell Carcinoma
   Metastatic Cancer to the Skin
   Molluscum Contagiosum
   Mycobacterium Fortuitum Complex Infection
   Mycobacterium Marinum Infection
   Mycobacterium Ulcerans Infection
   Necrobiosis Lipoidica
   Neisseria Gonorrhoeae Infections
   Nodular Melanoma
   Nodular Vasculitis
   Nongenital Herpes Simplex Virus Infection
   North American Blastomycosis
   Oral Hairy Leukoplakia
   Oropharyngeal Candidiasis
   Other Viral Infections
   Papulosquamous Conditions
   Pediculosis Capitis
   Pediculosis Pubis
   Photoallergic Drug Induced Photosensitivity
   Phototoxic Drug Induced Photosensitivity
   Pitted Keratolysis
   Pityriasis Versicolor
   Polyarteritis Nodosa
   Polymorphous Light Eruption
   Porphyria Cutanea Tarda
   Port-Wine Stain
   Premalignant and Malignant Skin Tumors
   Pressure Ulcers
   Pruritic Urticarial Papules
   Pseudoxanthoma Elasticum
   Pyogenic Granuloma
   Radiation Dermatitis
   Raynaud's Disease
   Reiter's Syndrome
   Rocky Mountain Spotted Fevers
   X-Linked Hyper-IgM Syndrome
   Xeroderma Pigmentosum
   Yellow Fever
   Yellow Nail Syndrome
   Zinc Deficiency

Skin Disorders || Contact Us || Tweet

Copyright © All Rights Reserved.

Disclaimer - The data contained in the Web pages is provided for the purpose of educational purposes and information only. It is not intended nor implied to be a substitute for professional medical advice and shall not create a physician - patient relationship. We are not responsible for any consequence resulted from using this information. Please always consult your physician for medical advices and treatment.