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Home :: Sneddon's Syndrome
Sneddon's Syndrome
A potentially life-threatening disease of unknown etiology occurring more often in females than males and manifesting mainly in skin and the central nervous system.
Causes of Sneddon's Syndrome
Unknown
Symptoms of Sneddon's Syndrome
The condition develops slowly over a variable time frame. Non-specific prodromal symptoms (headache, dizziness) often precede livedo reticularis by several years and this is followed by the development of focal neurological symptoms and then progressive cognitive impairment. Involvement of fundi, peripheral nerves, heart, and kidneys is frequent but usually asymptomatic. Livedo reticularis is a bluish mottling of skin, usually on the legs, and the appearance may be aggravated by exposure to cold.
Diagnosis
based on clinical symptoms and history.
Treatment
Longtime low-dose heparin, aspirin.
Note: Sneddon's syndrome is not identical with antiphospholipid syndrome although dermatologic manifestations (SLR) may be indistinguishable. Also, it may be associated (in a very small percentage of patients) with livedoid vasculitis-in this case, ulceration may occur around ankles or acrally.
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